7-Hydroxymethyl-2-pivaloylamino-1,8-naphthyridine
نویسندگان
چکیده
In the title compound, C14H17N3O2, the mean plane of the 1,8-naphthyridine ring system (r.m.s deviation = 0.020 Å) forms a dihedral angle of 23.4 (1)° with the acetamide moiety (r.m.s deviation = 0.001 Å). The mol-ecular structure is stabilized by an intra-molecular O-H⋯N hydrogen bond, which generates an S(5) ring motif. In the crystal, mol-ecules are linked into inversion dimers by pairs of N-H⋯O hydrogen bonds, generating 18-membered R 2 (2)(18) ring motifs.
منابع مشابه
Ethyl 7-pivaloylamino-1,8-naphthyridine-2-carboxylate sesquihydrate
In the title hydrate, C(16)H(19)N(3)O(3)·1.5H(2)O, both water mol-ecules are disordered: one over two adjacent sites in a 0.498 (5):0.502 (5) ratio and one lying near a crystallographic twofold axis. The dihedral angle between the pyridine rings of the organic moleucle is 1.47 (6)°. In the crystal, the components are linked by N-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds, forming sheets lying parallel...
متن کاملSynthesis and spectral characterisation of Mn(II) complexes with amide group containing 1,8-Naphthyridines
Complexes of Mn(II) with 1,8-naphthyride containing amide group ligands 2-amino1-8,naphthyride-3-carboxamide (ANC), 2-amino-N-phenyl-1,8-naphthyride-3-carboxamide (APNC), 2-amino-N-(p-methyl phenyl)-1,8-naphthyridine-3-carboxamide(AMPNC), 2-amino-N-)p-bromo phenyl)1,8-naphthyridine-3-carboxamide(ABPNC), 2-amino-N-(p-chloro phenyl)-1,8-naphthyridine3-carboxamide (ACPNC), 2-amino-N-(p-methoxy phe...
متن کاملInfluence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization
Here, we report on a significant effect of substitutions on the binding affinity of a series of 2-amino-1,8-naphthyridines, i.e., 2-amino-1,8-naphthyridine (AND), 2-amino-7-methyl-1,8-naphthyridine (AMND), 2-amino-5,7-dimethyl-1,8-naphthyridine (ADMND) and 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND), all of which can bind to cytosine opposite an AP site in DNA duplexes. Fluorescence titra...
متن کاملSynthesis and spectral characterisation of Ni(II) complexes with amide group ligands containing 1,8-Naphthyridines
Complexes of Nickel(II) with 2-amino-1,8-naphthyridine-3-carboxamide (ANC), 2-amino-Nphenyl-1,8-naphthyridine-3-carboxamide (APNC), 2-amino-N-(p-methyl phenyl)-1,8-naphthyridine-3carboxamide(AMPNC), 2-amino-N-(p-bromo phenyl)1,8-naphthyridine-3-carboxamide(ABPNC), 2amino-N-(p-chloro phenyl)-1,8-naphthyridine-3-carboxamide (ACPNC), 2-amino-N-(p-methoxy phenyl)1,8-naphthyridine-3-carboxamide (AMY...
متن کاملRatiometric fluorescence detection of pyrimidine/purine transversion by using a 2-amino-1,8-naphthyridine derivative.
A new class of abasic site-binding fluorescence ligands, Naph-NBD in which 7-nitrobenzo-2-oxa-1,3-diazole (NBD) is connected to 2-amino-7-methyl-1,8-naphthyridine (Naph) by a propylene linker, is presented for the ratiometric assay for SNPs typing. In solutions buffered to pH 7.0 (I = 0.11 M, at 5 degrees C), Naph-NBD is found to selectively recognize pyrimidine bases over purine bases opposite...
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عنوان ژورنال:
دوره 69 شماره
صفحات -
تاریخ انتشار 2013